With one of the fastest growing HIV/AIDS epidemic in the world, the USAID Dialogue on HIV and TB Project targets most-at-risk populations (MARPs) most likely to contract or transmit HIV: people who inject drugs (PWID), sex workers (SWs), migrants, men who have sex with men (MSM), prisoners, and people living with HIV (PLWH). Risk for TB infection is higher among IDUs, prisoners and migrants, but is particularly dangerous for PLWH. TB can pose a greater threat to the lives of PLWH and, in Central Asia where TB is registered at epidemic levels and drug resistant TB is on rise, PLWH are especially vulnerable to TB. Thus, TB interventions specifically target these four groups under the project.